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Article

Enhanced uptake of potassium or glycine betaine or export of cyclic-di-AMP restores osmoresistance in a high cyclic-di-AMP Lactococcus lactis mutant.

PLoS genetics - 1 Aug 2018

Pham Huong Thi, Nhiep Nguyen Thi Hanh, Vu Thu Ngoc Minh, Huynh TuAnh Ngoc, Zhu Yan, Huynh Anh Le Diep, Chakrabortti Alolika, Marcellin Esteban, Lo Raquel, Howard Christopher B, Bansal Nidhi, Woodward Joshua J, Liang Zhao-Xun, Turner Mark S

Abstract excerpt

The broadly conserved bacterial signalling molecule cyclic-di-adenosine monophosphate (c-di-AMP) controls osmoresistance via its regulation of potassium (K+) and compatible solute uptake. High levels of c-di-AMP resulting from inactivation of c-di-AMP phosphodiesterase activity leads to poor growth of bacteria under high osmotic conditions. To better understand how bacteria can adjust in response to excessive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30074984
DOI: 10.1371/journal.pgen.1007574
PMCID: PMC6108528

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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