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Article

A Novel Phosphodiesterase of the GdpP Family Modulates Cyclic di-AMP Levels in Response to Cell Membrane Stress in Daptomycin-Resistant Enterococci.

Antimicrobial agents and chemotherapy - 1 Mar 2017

Wang Xu, Davlieva Milya, Reyes Jinnethe, Panesso Diana, Arias Cesar A, Shamoo Yousif

Abstract excerpt

Substitutions in the LiaFSR membrane stress pathway are frequently associated with the emergence of antimicrobial peptide resistance in both Enterococcus faecalis and Enterococcus faecium Cyclic di-AMP (c-di-AMP) is an important signal molecule that affects many aspects of bacterial physiology, including stress responses. We have previously identified a mutation in a gene (designated yybT) in E. faecalis that was...

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Identifiers

PMID: 28069645
DOI: 10.1128/AAC.01422-16
PMCID: PMC5328519

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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