Article

Towards Identifying a Molecular Activator of Spreading Depolarization Generated by the Ischemic Brain

2026-04-30

Abstract excerpt

Spreading depolarizations (SDs) are waves of mass depolarization that propagate through gray matter following Na + /K + -ATPase (NKA) failure because of stroke, traumatic brain injury or sudden cardiac arrest. SDs expand the initial site of neuronal injury and worsen clinical outcomes. The molecular events underlying SD initiation and propagation are not well understood. In this rodent study, we hypothesized tha...

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Literature Corpus work: ee7c52f9-818d-50e1-b8dc-dd970bcf36a7
DOI: 10.64898/2026.04.27.721086

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