Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Initiation of migraine-related cortical spreading depolarization by hyperactivity of GABAergic neurons and NaV1.1 channels

7 Sept 2021

Abstract excerpt

Spreading depolarizations (SDs) are involved in migraine, epilepsy, stroke, traumatic brain injury, and subarachnoid hemorrhage. However, the cellular origin and specific differential mechanisms are not clear. Increased glutamatergic activity is thought to be the key factor for generating cortical spreading depression (CSD), a pathological mechanism of migraine. Here, we show that acute pharmacological activation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epilepsy research and treatment
Share to Migraine and Headache Studies
Share to Neuroscience of respiration and sleep

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34491914
DOI: 10.1172/jci142203

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Initiation of migraine-related cortical spreading depolarization by hyperactivity of GABAergic neurons and NaV1.1 channelsPMID 34491914Read ↗

Hyperexcitable interneurons trigger cortical spreading depression in an Scn1a migraine model.Semantic proximity Read ↗

Modeling NaV1.1/SCN1A sodium channel mutations in a microcircuit with realistic ion concentration dynamics suggests differential GABAergic mechanisms leading to hyperexcitability in epilepsy and hemiplegic migraine.Semantic proximity Read ↗

Spreading depression and the clinical correlates of migraine.Semantic proximity Read ↗

First FHM3 mouse model shows spontaneous cortical spreading depolarizationsSemantic proximity Read ↗

Idealized multiple-timescale model of cortical spreading depolarization initiation and pre-epileptic hyperexcitability caused by NaV1.1/SCN1A mutations.Semantic proximity Read ↗

Migraine: Calcium Channels and Glia.Semantic proximity Read ↗

Mechanisms underlying the increased susceptibility to initiation of cortical spreading depression in a genetic mouse model of migraineSemantic proximity Read ↗

Spontaneous and optogenetically induced cortical spreading depolarization in familial hemiplegic migraine type 1 mutant miceSemantic proximity Read ↗

Pathogenesis and Preventive Pharmacotherapy of Migraine Aura: A Critical Review of Cortical Spreading Depolarization Mechanisms, Drug Repurposing Evidence, and the Emerging Therapeutic PipelineSemantic proximity Read ↗

In vivo imaging reveals that pregabalin inhibits cortical spreading depression and propagation to subcortical brain structures.Semantic proximity Read ↗

Enhanced excitatory transmission at cortical synapses as the basis for facilitated spreading depression in Ca(v)2.1 knockin migraine mice.Semantic proximity Read ↗

Migraine: new molecular mechanisms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.