Article

Atypical plume-like events drive glutamate accumulation in metabolic stress conditions

2025-02-06

Abstract excerpt

Neural glutamate homeostasis plays a key role in health and disease. In ischemic conditions, such as stroke, this homeostasis is severely disrupted since energy depletion and ion imbalances lead to more glutamate release and less uptake. We here used the fluorescent glutamate sensor SF-iGluSnFR(A184V) to probe the effects of chemical ischemia on extracellular glutamate dynamics in situ , using organotypic slice c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 156286bb-a9d9-56fd-b1c7-3ca02feb6680
DOI: 10.1101/2025.02.05.636645

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Atypical plume-like events drive glutamate accumulation in metabolic stress conditionsDOI 10.1101/2025.02.05.636645Read

Distinct effects of different metabolic stress models on human-derived neuronal networksSemantic proximity Read

Spatiotemporally selective ATP events from astrocytes encode injury information and guide sustained microglial responseSemantic proximity Read

Glioblastoma disrupts cortical network activity at multiple spatial and temporal scalesSemantic proximity Read

Malignant astrocyte swelling and impaired glutamate clearance drive the expansion of injurious spreading depolarization fociSemantic proximity Read

Genetically Encoded Glutamate Indicators with Altered Color and Topology.Semantic proximity Read

High-throughput measurements of neuronal activity in single human iPSC-derived glutamate neuronsSemantic proximity Read

Initiation of migraine-related cortical spreading depolarization by hyperactivity of GABAergic neurons and NaV1.1 channelsSemantic proximity Read

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice.Semantic proximity Read

Microglial Calcium Signaling is Attuned to Neuronal ActivitySemantic proximity Read

Whole brain fluorescence imaging in <i>Drosophila</i> reveals spreading depression and its initiation, propagation, and resilience dynamicsSemantic proximity Read

Synaptic Zn <sup>2+</sup> contributes to deleterious consequences of spreading depolarizationsSemantic proximity Read

A GRAB sensor reveals activity-dependent non-vesicular somatodendritic adenosine releaseSemantic proximity Read