Article

RAS and PP2A activities converge on epigenetic gene regulation

2022-05-12

Abstract excerpt

<h4>ABSTRACT</h4> RAS-mediated human cell transformation requires inhibition of the tumor suppressor Protein Phosphatase 2A (PP2A). Both RAS and PP2A mediate their effects by phosphoregulation, but phosphoprotein targets and cellular processes in which RAS and PP2A activities converge in human cancers have not been systematically analyzed. Here, based on mass spectrometry phosphoproteome data we discover that pho...

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Literature Corpus work: c807e9a5-de48-5641-b467-0160cf426a7a
DOI: 10.1101/2022.05.11.491459

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