Article

Structure of the SHOC2–MRAS–PP1C complex provides insights into RAF activation and Noonan syndrome

2022-05-10

Abstract excerpt

<h4>ABSTRACT</h4> SHOC2 acts as a strong synthetic lethal interactor with MEK inhibitors in multiple KRAS cancer cell lines. SHOC2 forms a heterotrimeric complex with MRAS and PP1C that is essential for regulating RAF and MAPK-pathway activation by dephosphorylating a specific phosphoserine on RAF kinases. Here we present the high-resolution crystal structure of SHOC2-MRAS-PP1C (SMP) complex and apo-SHOC2. Our st...

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Literature Corpus work: a8f0dee9-5752-5f52-a334-a284b6968b7d
DOI: 10.1101/2022.05.10.491335

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