Article

Oncogenic PKA signaling stabilizes MYC oncoproteins via an aurora kinase A-dependent mechanism

2021-04-16

Abstract excerpt

Genetic alterations that activate protein kinase A (PKA) signaling are found across many tumor types, but their downstream oncogenic mechanisms are poorly understood. We used global phosphoproteomics and kinome activity profiling to map the conserved signaling outputs driven by diverse genetic changes that activate PKA in human cancer, including melanoma and fibrolamellar carcinoma (FLC). We define two consensus n...

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Literature Corpus work: 052ed4af-8c3c-56c8-bf41-d9b56017156a
DOI: 10.1101/2021.04.16.438110

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Oncogenic PKA signaling stabilizes MYC oncoproteins via an aurora kinase A-dependent mechanismDOI 10.1101/2021.04.16.438110Read

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