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The role of GATA2 in the expression of the soluble decoy receptor ST2/IL1RL1 in human and mouse mast cells

2025-02-24

Abstract excerpt

The ST2/IL1RL1 gene encodes a receptor subunit for IL-33. The ST2/IL1RL1 gene is transcribed and translated to two splice variants, full-length ST2 (ST2L) and soluble ST2 (sST2). ST2L is expressed on cell surface as membrane bound molecule and forms a heterodimer with IL-1RAcP, which plays an important role in Th2 transduces a signaling of IL-33. In contrast, sST2 blocks the IL-33-signaling via functioning as a...

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Identifiers and source

Literature Corpus work
c80687a3-2cdf-5dcb-90a1-09ae3e009441
DOI
10.1101/2025.02.19.638998
Open publication

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