Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The STAT5–GATA2 Pathway Is Critical in Basophil and Mast Cell Differentiation and Maintenance

23 Mar 2015

Abstract excerpt

Transcription factor GATA binding protein 2 (GATA2) plays critical roles in hematopoietic stem cell survival and proliferation, granulocyte-monocyte progenitor differentiation, and basophil and mast cell differentiation. However, precise roles of GATA2 in basophil and mast cell differentiation and maintenance have not been delineated. We have identified GATA2 as an essential transcription factor in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asthma and respiratory diseases
Share to Mast cells and histamine
Share to Polyamine Metabolism and Applications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25801432
DOI: 10.4049/jimmunol.1500018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The STAT5–GATA2 Pathway Is Critical in Basophil and Mast Cell Differentiation and MaintenancePMID 25801432Read ↗

GATA Transcription Factors: Basic Principles and Related Human Disorders.Semantic proximity Read ↗

GATA family transcriptional factors: emerging suspects in hematologic disordersSemantic proximity Read ↗

Unveiling GATA3 Signaling Pathways in Health and Disease: Mechanisms, Implications, and Therapeutic PotentialSemantic proximity Read ↗

Pathogenic GATA2 genetic variants utilize an obligate enhancer mechanism to distort a multilineage differentiation program.Semantic proximity Read ↗

Role of the pioneer transcription factor GATA2 in health and disease.Semantic proximity Read ↗

GATA1 function, a paradigm for transcription factors in hematopoiesis.Semantic proximity Read ↗

Master regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignanciesSemantic proximity Read ↗

GATA-related hematologic disorders.Semantic proximity Read ↗

SATB1 dictates expression of multiple genes including IL-5 involved in human T helper cell differentiationSemantic proximity Read ↗

Essential and instructive roles of GATA factors in eosinophil development.Semantic proximity Read ↗

GATA transcription factors and hematological diseases.Semantic proximity Read ↗

Unveiling GATA3 Signalling Pathways in Health and Disease: Mechanisms, Implications, and Therapeutic PotentialSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.