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In vivo imaging of myonuclei during spontaneous muscle contraction reveals non-uniform nuclear mechanical dynamics in Nesprin/klar mutants

2019-05-20

Abstract excerpt

Muscle contractions produce reiterated cytoplasmic mechanical variations, which impact the nuclear membrane and potentially influence nuclear mechanotransduction. It is unclear, however, whether the mechanical dynamics of individual myonuclei changes during each contractile wave, and whether mutants whose connection to the cytoskeleton is impaired are subjected to different mechanical input. To monitor nuclear mec...

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Literature Corpus work: c7f8848a-1b5a-52b8-a6ac-71e5900877d0
DOI: 10.1101/643015

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<i>In vivo</i> imaging of myonuclei during spontaneous muscle contraction reveals non-uniform nuclear mechanical dynamics in <i>Nesprin/klar</i> mutants

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