Article
Nexilin mutations destabilize cardiac Z-disks and lead to dilated cardiomyopathy.
Nature medicine - 1 Nov 2009
Hassel David, Dahme Tillman, Erdmann Jeanette, Meder Benjamin, Huge Andreas, Stoll Monika, Just Steffen, Hess Alexander, Ehlermann Philipp, Weichenhan Dieter, Grimmler Matthias, Liptau Henrike, Hetzer Roland, Regitz-Zagrosek Vera, Fischer Christine, Nürnberg Peter, Schunkert Heribert, Katus Hugo A, Rottbauer Wolfgang
Abstract excerpt
Z-disks, the mechanical integration sites of heart and skeletal muscle cells, link anchorage of myofilaments to force reception and processing. The key molecules that enable the Z-disk to persistently withstand the extreme mechanical forces during muscle contraction have not yet been identified. Here we isolated nexilin (encoded by NEXN) as a novel Z-disk protein. Loss of nexilin in zebrafish led to perturbed...
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