Article
Lamins and nesprin-1 mediate inside-out mechanical coupling in muscle cell precursors through FHOD1.
Scientific reports - 28 Apr 2017
Schwartz Christine, Fischer Martina, Mamchaoui Kamel, Bigot Anne, Lok Thevy, Verdier Claude, Duperray Alain, Michel Richard, Holt Ian, Voit Thomas, Quijano-Roy Suzanna, Bonne Gisèle, Coirault Catherine
Abstract excerpt
LINC complexes are crucial for the response of muscle cell precursors to the rigidity of their environment, but the mechanisms explaining this behaviour are not known. Here we show that pathogenic mutations in LMNA or SYNE-1 responsible for severe muscle dystrophies reduced the ability of human muscle cell precursors to adapt to substrates of different stiffness. Plated on muscle-like stiffness matrix, mutant...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.