Article

Senescent Preosteoclast Secretome Promotes Metabolic Syndrome-Associated Osteoarthritis through Cyclooxygenase 2

2022-05-05

Abstract excerpt

<h4>Background</h4> Metabolic syndrome–associated osteoarthritis (MetS-OA) is a distinct osteoarthritis phenotype defined by the coexistence of MetS or its individual components. Despite the high prevalence of MetS-OA, its pathogenic mechanisms are unclear. The aim of this study was to determine the role of cellular senescence in the development of MetS-OA. <h4>Methods</h4> Analysis of the human osteoarthritis i...

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Literature Corpus work: c7f60d9e-a44f-57cb-b275-0f76d8133fae
DOI: 10.1101/2022.05.05.490792

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