Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ESC-sEVs alleviate non-early-stage osteoarthritis progression by rejuvenating senescent chondrocytes via FOXO1A-autophagy axis but not inducing apoptosis

19 Oct 2024

Abstract excerpt

Osteoarthritis (OA) is a common joint degenerative disease which currently lacks satisfactory disease-modifying treatments. Oxidative stress-mediated senescent chondrocytes accumulation is closely associated with OA progression, which abrogates cartilage metabolism homeostasis by secreting senescence-associated secretory phenotype (SASP) factors. Numerous studies suggested mesenchymal stem cells-derived small...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related molecular mechanisms research
Share to Extracellular vesicles in disease
Share to Osteoarthritis Treatment and Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39433168
DOI: 10.1016/j.phrs.2024.107474

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ESC-sEVs alleviate non-early-stage osteoarthritis progression by rejuvenating senescent chondrocytes via FOXO1A-autophagy axis but not inducing apoptosisPMID 39433168Read ↗

The role of chondrocyte senescence in osteoarthritis pathogenesis and therapeutic implicationsSemantic proximity Read ↗

Cellular Aging, Senescence and Autophagy Processes in Osteoarthritis.Semantic proximity Read ↗

Single‑cell sequencing, genetics, and epigenetics reveal mesenchymal stem cell senescence in osteoarthritis (Review)Semantic proximity Read ↗

Mechanisms and therapeutic implications of cellular senescence in osteoarthritis.Semantic proximity Read ↗

Multiomic identification of senescent stem cell populations critical for osteoarthritis progression and therapy in subchondral bonesSemantic proximity Read ↗

Age-related degeneration of articular cartilage in the pathogenesis of osteoarthritis: molecular markers of senescent chondrocytes.Semantic proximity Read ↗

Human ESC‐sEVs alleviate age‐related bone loss by rejuvenating senescent bone marrow‐derived mesenchymal stem cellsSemantic proximity Read ↗

Cellular senescence in osteoarthritis and anti-aging strategies.Semantic proximity Read ↗

Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression.Semantic proximity Read ↗

Targeting cellular senescence as a novel treatment for osteoarthritis.Semantic proximity Read ↗

Mechanical stress abnormalities promote chondrocyte senescence - The pathogenesis of knee osteoarthritisSemantic proximity Read ↗

Reprogramming of lipid secretome in senescent synovial fibroblasts ameliorate osteoarthritis developmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.