Metabolic syndrome-osteoarthritis axis: Beyond mechanical loading toward a cardiometabolic OA phenotype.

Abstract excerpt

Osteoarthritis (OA) has long been framed as a mechanically driven "wear-and-tear" disorder. Increasing epidemiological and translational evidence indicates that metabolic syndrome (MetS)-including obesity, insulin resistance/hyperglycaemia, dyslipidaemia, and hypertension-acts as a key disease modifier in a substantial subset of patients. MetS-related OA may represent a cardiometabolic endotype with...

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