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Article

Molecular dissection of lubeluzole use-dependent block of voltage-gated sodium channels discloses new therapeutic potentials.

Molecular pharmacology - 1 Feb 2013

Desaphy Jean-François, Carbonara Roberta, Costanza Teresa, Lentini Giovanni, Cavalluzzi Maria Maddalena, Bruno Claudio, Franchini Carlo, Camerino Diana Conte

Abstract excerpt

Lubeluzole, which acts on various targets in vitro, including voltage-gated sodium channels, was initially proposed as a neuroprotectant. The lubeluzole structure contains a benzothiazole moiety [N-methyl-1,3-benzothiazole-2-amine (R-like)] related to riluzole and a phenoxy-propranol-amine moiety [(RS)-1-(3,4-difluorophenoxy)-3-(piperidin-1-yl)propan-2-ol (A-core)] recalling propranolol. Both riluzole and...

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Identifiers

PMID: 23175529
DOI: 10.1124/mol.112.080804

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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