Article

COMPASS-mediated epigenetic regulation of transcription accelerates forgetting with age

2026-04-27

Abstract excerpt

<title>Abstract</title> <p>The molecular regulation of forgetting and its acceleration with age are not understood. Here we discovered that active gene transcription, rather than solely mRNA translation, is required for forgetting. We found that the subunits of SET1/COMPASS, a conserved histone methyltransferase complex associated with active transcription, are upregulated in aged C. elegans neurons, mirroring th...

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Literature Corpus work: c7e5a7e1-7029-5ef5-8109-0622b68a295d
DOI: 10.21203/rs.3.rs-9395284/v1

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