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Article

Forgetting in C. elegans is accelerated by neuronal communication via the TIR-1/JNK-1 pathway.

Cell reports - 28 Mar 2013

Inoue Akitoshi, Sawatari Etsuko, Hisamoto Naoki, Kitazono Tomohiro, Teramoto Takayuki, Fujiwara Manabi, Matsumoto Kunihiro, Ishihara Takeshi

Abstract excerpt

The control of memory retention is important for proper responses to constantly changing environments, but the regulatory mechanisms underlying forgetting have not been fully elucidated. Our genetic analyses in C. elegans revealed that mutants of the TIR-1/JNK-1 pathway exhibited prolonged retention of olfactory adaptation and salt chemotaxis learning. In olfactory adaptation, conditioning induces attenuation of...

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PMID: 23523351
DOI: 10.1016/j.celrep.2013.02.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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