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Neuronal activation of Gαq EGL-30/GNAQ late in life rejuvenates cognition across species

1 Sept 2023

Abstract excerpt

signaling pathways are highly conserved between C. elegans and mammals, and murine Gnaq is enriched in hippocampal neurons and declines with age. We found that activation of EGL-30 in aged worms triples memory span, and GNAQ gain of function significantly improved memory in aged mice: GNAQ(gf) in hippocampal neurons of 24-month-old mice (equivalent to 70- to 80-year-old humans) rescued age-related impairments in...

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PMID: 37713310
DOI: 10.1016/j.celrep.2023.113151

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