Article

Neuronal Activation of the Gαq Protein EGL-30/GNAQ Late in Life Rejuvenates Cognition Across Species

2023-06-07

Abstract excerpt

Cognitive decline is perhaps the most devastating aging loss. EGL-30/GNAQ and Gαq signaling pathways are highly conserved between C. elegans and mammals. We find that activation of EGL-30 in aged worms at least triples memory span, and we wondered if this highly conserved pathway could also improve memory in very old mice. Murine Gnaq is enriched in hippocampal excitatory neurons and declines with age. Furthermo...

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Literature Corpus work: 78a82fe8-7c04-5809-b42f-bbb4e43c23a0
DOI: 10.1101/2023.06.06.543909

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