Article

Histamine H 1 receptor-mediated CREB phosphorylation via G q protein signaling and arrestin modulation

2025-12-02

Abstract excerpt

<title>Abstract</title> <p> Histamine H <sub>1</sub> receptors mediate multiple physiological and pathophysiological processes, including inflammation and allergy, by regulating downstream gene expression via transcription factors. Agonist binding activates G <sub>q</sub> proteins, increasing intracellular Ca²⁺ and activating protein kinase C (PKC) and stimulating G protein-coupled receptor kinases (ERK) and...

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Literature Corpus work: c7c4f538-25ba-5c96-ab36-ad916e28825d
DOI: 10.21203/rs.3.rs-8024318/v1

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