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Article

Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation.

The Journal of biological chemistry - 21 Apr 2006

Gesty-Palmer Diane, Chen Minyong, Reiter Eric, Ahn Seungkirl, Nelson Christopher D, Wang Shuntai, Eckhardt Allen E, Cowan Conrad L, Spurney Robert F, Luttrell Louis M, Lefkowitz Robert J

Abstract excerpt

Parathyroid hormone (PTH) regulates calcium homeostasis via the type I PTH/PTH-related peptide (PTH/PTHrP) receptor (PTH1R). The purpose of the present study was to identify the contributions of distinct signaling mechanisms to PTH-stimulated activation of the mitogen-activated protein kinases (MAPK) ERK1/2. In Human embryonic kidney 293 (HEK293) cells transiently transfected with hPTH1R, PTH stimulated a robust...

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Identifiers

PMID: 16492667
DOI: 10.1074/jbc.M513380200

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PTH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation.PMID 16492667Read ↗

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