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Infection of 5xFAD mice with a mouse-adapted SARS-CoV-2 does not alter Alzheimer’s disease neuropathology yet induces wide-spread changes in gene expression across diverse cell types

2025-12-22

Abstract excerpt

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia. It is characterized by cognitive decline and accumulation of amyloid beta (Aβ) plaques and neurofibrillary tangles. Accumulating evidence indicates that viral infection may worsen and/or increase development of established AD pathology. The COVID-19 pandemic has brought attention to the link between SARS-CoV-2 i...

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Literature Corpus work: 2a088f03-9c2b-528e-80c2-c498afb3faf8
DOI: 10.64898/2025.12.19.695600

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