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Article

Faulty Metabolism: A Potential Instigator of an Aggressive Phenotype in Cdk5-dependent Medullary Thyroid Carcinoma

2023-06-14

Abstract excerpt

Mechanistic modeling of cancers such as Medullary Thyroid Carcinoma (MTC) to emulate patient-specific phenotypes is challenging. The discovery of potential diagnostic markers and druggable targets in MTC urgently requires clinically relevant animal models. Here we established orthotopic mouse models of MTC driven by aberrantly active Cdk5 using cell-specific promoters. Each of the two models elicits distinct growt...

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Literature Corpus work
c7b4204e-91d7-51f7-939d-0d14dcbfba94
DOI
10.1101/2023.06.13.544755
Open publication

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Faulty Metabolism: A Potential Instigator of an Aggressive Phenotype in Cdk5-dependent Medullary Thyroid CarcinomaDOI 10.1101/2023.06.13.544755
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