Convergent Mechanistic Pathways Driving the Anaplastic Phenotype in Thyroid Cancer.

doi:10.3390/ijms27167156

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Article

Convergent Mechanistic Pathways Driving the Anaplastic Phenotype in Thyroid Cancer.

International journal of molecular sciences - 10 Aug 2026

Centone Anthony, DeSouza Nicole R, Yang Nan, Desai Shaun, Moscatello Augustine, Garber David, Hemmerdinger Steven, Rotsides Janine M, Yao Mike, Tiwari Raj K, Geliebter Jan, Li Xiu-Min

Abstract excerpt

Anaplastic thyroid carcinoma (ATC) is a rare, highly aggressive follicular cell-derived malignancy characterized by rapid progression, profound dedifferentiation, and marked resistance to conventional therapy. Despite frequent involvement of major oncogenic pathways, ATC does not exhibit a universal driver mutation, suggesting that its pathogenesis reflects convergence upon shared biological hallmarks rather than...

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Share to Endoplasmic Reticulum Stress
Share to CDKN2A gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to TP53 gene

Share to Phenotype

Share to Signal Transduction

Share to Thyroid Carcinoma, Anaplastic

Share to Thyroid Neoplasms

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Identifiers

PMID: 42653161
DOI: 10.3390/ijms27167156
PMCID: PMC13513259

Genes

CDKN2A
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.