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Article

An Integrative Multi-Omics Analysis of The Molecular Links between Aging and Aggressiveness in Thyroid Cancers

17 Nov 2022

Abstract excerpt

Aging modifies risk in all cancers, but age is used as a clinical staging criterion uniquely in thyroid cancer (TC). The molecular drivers of age-dependent TC onset and aggressiveness remain poorly understood. We applied an integrative, multi-omics data analysis approach to characterize these signatures. Our analysis reveals that aging, independent of BRAF<sup>V600E</sup> mutational status, drives a significant...

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PMID: 37191407
DOI: 10.14336/ad.2022.1021

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