Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deciphering functional intra-tumoral heterogeneity in BRAFV600E-driven mouse thyroid cancer reveals EMT trajectory and metabolic remodeling.

Oncogene - 1 May 2026

Yu Jing, Shen Siyi, Luo Rongkui, Qiu Tianyuan, Chen Jingjing, Kong Wenqing, Ma Ruisen, Yan Ying, Niu Zhoumin, Ma Mei, Li Zhuoyang, Wu Yuting, Li Yuying, Zhang Ling, Ying Hao

Abstract excerpt

A better understanding of functional heterogeneity of tumor cells may lead to the improvement of the diagnosis and development of effective therapies for patients with papillary thyroid cancer (PTC). Here, the transcriptional heterogeneity and hierarchical trajectory of malignant thyrocytes were investigated by single-cell RNA sequencing analysis in an adult-onset autochthonous mouse model of PTC driven by a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Models, Animal
Share to Epithelial-Mesenchymal Transition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Metformin

Share to Proto-Oncogene Proteins B-raf

Share to Thyroid Cancer, Papillary

Share to Thyroid Neoplasms

Source

Identifiers

PMID: 41935217
DOI: 10.1038/s41388-026-03742-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deciphering functional intra-tumoral heterogeneity in BRAFV600E-driven mouse thyroid cancer reveals EMT trajectory and metabolic remodeling.PMID 41935217Read ↗

Single-cell transcriptomic analysis of the tumor ecosystems underlying initiation and progression of papillary thyroid carcinomaSemantic proximity Read ↗

Dual targeting of MAPK and PI3K pathways unlocks redifferentiation of <i>Braf</i> -mutated thyroid cancer organoidsSemantic proximity Read ↗

Dual targeting of MAPK and PI3K pathways unlocks redifferentiation of Braf-mutated thyroid cancer organoids.Semantic proximity Read ↗

High aggressiveness of papillary thyroid cancer: from clinical evidence to regulatory cellular networksSemantic proximity Read ↗

Mutation-specific dynamics of dedifferentiation trajectories and tumor-stromal interactions in thyroid cancer.Semantic proximity Read ↗

Single‐Cell RNA Sequencing Reveals the Heterogeneity in Differentiation Trajectory and Tumor Microenvironment Leading to More Aggressive Phenotypes of Papillary Thyroid Cancer in Children and Young Adult PatientsSemantic proximity Read ↗

Telomerase Upregulation Induces Progression of Mouse BrafV600E-Driven Thyroid Cancers and Triggers Nontelomeric Effects.Semantic proximity Read ↗

Papillary thyroid cancer organoids harboring BRAFV600E mutation reveal potentially beneficial effects of BRAF inhibitor-based combination therapies.Semantic proximity Read ↗

Faulty Metabolism: A Potential Instigator of an Aggressive Phenotype in Cdk5-dependent Medullary Thyroid CarcinomaSemantic proximity Read ↗

p53 constrains progression to anaplastic thyroid carcinoma in a Braf-mutant mouse model of papillary thyroid cancer.Semantic proximity Read ↗

Telomerase reactivation induces progression of mouse Braf <sup>V600E</sup> -driven thyroid cancers without telomere lengtheningSemantic proximity Read ↗

Leveraging the transcriptome-phenotype relationship to guide clinical management of papillary thyroid cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.