Article

Spatiotemporal dynamics of tumor - CAR T-cell interaction following local administration in solid cancers

2024-08-30

Abstract excerpt

The success of chimeric antigen receptor (CAR) T-cell therapy in treating hematologic malignancies has generated widespread interest in translating this technology to solid cancers. However, issues like tumor infiltration, the immunosuppressive tumor microenvironment, and tumor heterogeneity limit its efficacy in the solid tumor setting. Recent experimental and clinical studies propose local administration directl...

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Literature Corpus work: 72fa7b19-8c44-5400-9a3c-2b43e8f8856e
DOI: 10.1101/2024.08.29.610392

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