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Rapid discovery of high-affinity antibodies via massively parallel sequencing, ribosome display and affinity screening

9 Oct 2023

Abstract excerpt

Abstract Developing therapeutic antibodies is laborious and costly. Here we report a method for antibody discovery that leverages the Illumina HiSeq platform to, within 3 days, screen in the order of 10 8 antibody–antigen interactions. The method, which we named ‘deep screening’, involves the clustering and sequencing of antibody libraries, the conversion of the DNA clusters into complementary RNA clusters...

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PMID: 37814006
DOI: 10.1038/s41551-023-01093-3

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