DNA methylation maintenance by DNMT1 is essential for human trophoblast stem cell homeostasis and differentiation

Abstract excerpt

Proliferation of cytotrophoblasts (CTBs) and their differentiation into invasive extravillous trophoblasts (EVTs) are critical processes in early placental development. Defects in these processes are associated with adverse pregnancy outcomes, including recurrent pregnancy loss (RPL). There is evidence that reduced expression of the maintenance DNA methyltransferase DNMT1 in the placenta occurs in pregnancy loss a...

Topics

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• Cell Culture Techniques
• Choriocarcinoma
• Epigenetics and DNA Methylation
• Epigenomics
• Neonatal Respiratory Health Research
• Oligonucleotide Array Sequence Analysis
• Pregnancy and preeclampsia studies
• Prenatal Screening and Diagnostics

Identifiers and source

Literature Corpus work

c7a0cad6-b847-553b-aca1-47c2adf041e9

DOI

10.64898/2026.07.02.735425