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Rif1 and Hmgn3 regulate the conversion of murine trophoblast stem cells

1 Mar 2022

Abstract excerpt

The appearance of trophectoderm (TE) is a hallmark event in preimplantation development during murine embryogenesis. However, little is known about the mechanisms underlying TE specification. We find that the depletion of Rif1 breaks down the barrier to the transition from embryonic stem cells (ESCs) to trophoblast stem cells (TSCs). Rif1-null-induced TSCs show typical TE properties and the potential to...

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PMID: 35354046
DOI: 10.1016/j.celrep.2022.110570

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