Potential role of epigenetic mechanisms in regulation of trophoblast differentiation, migration, and invasion in the human placenta

Abstract excerpt

The proper establishment and organogenesis of the placenta is crucial for intrauterine fetal growth and development. Endometrial invasion by the extravillous trophoblast cells, as well as formation of the syncytiotrophoblast (STB), are of vital importance for placental function. Trophoblast migration and invasion is often compared to tumor metastasis, which uses many of the same molecular mechanisms. However,...

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