Article

Epigenetic changes regulating the epithelial-mesenchymal transition in human trophoblast differentiation

2024-07-04

Abstract excerpt

The phenotype of human placental extravillous trophoblast (EVT) at the end of pregnancy reflects both first trimester differentiation from villous cytotrophoblast (CTB) and later gestational changes, including loss of proliferative and invasive capacity. Invasion abnormalities are central to two major placental pathologies, preeclampsia and placenta accreta spectrum, so characterization of the corresponding normal...

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Literature Corpus work: 408e1ee8-2e4b-596a-b977-4a18aef4873f
DOI: 10.1101/2024.07.02.601748

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