Article

ACSL3 is a novel GABARAPL2 interactor that links ufmylation and lipid droplet biogenesis

2020-01-01

Abstract excerpt

While studies of ATG genes in knockout models led to an explosion of knowledge about the functions of autophagy components, the exact roles of LC3/GABARAP proteins are still poorly understood. A major drawback for their understanding is that the available interactome data was largely acquired using overexpression systems. To overcome these limitations, we employed CRISPR/Cas9-based genome-editing to generate a pan...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5a1d8870-2f09-5cd3-a23c-d1c69aa0fbbc
DOI: 10.1101/2020.01.01.892521

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ACSL3 is a novel GABARAPL2 interactor that links ufmylation and lipid droplet biogenesisDOI 10.1101/2020.01.01.892521Read

ACSL3 is a novel GABARAPL2 interactor that links ufmylation and lipid droplet biogenesisSemantic proximity Read

LC3 and GATE‐16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesisSemantic proximity Read

Atg8 family LC3/GABARAP proteins are crucial for autophagosome–lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvationSemantic proximity Read

LC3/GABARAP family proteins: autophagy‐(un)related functionsSemantic proximity Read

GABARAPs and LC3s have opposite roles in regulating ULK1 for autophagy inductionSemantic proximity Read

Role of the mammalian ATG8/LC3 family in autophagy: differential and compensatory roles in the spatiotemporal regulation of autophagySemantic proximity Read

ATG8-Binding UIM Proteins Define a New Class of Autophagy Adaptors and ReceptorsSemantic proximity Read

ATG8-Binding UIM Proteins Define a New Class of Autophagy Adaptors and ReceptorsSemantic proximity Read

The functions of Atg8-family proteins in autophagy and cancer: linked or unrelated?Semantic proximity Read

Atg4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation systemSemantic proximity Read

DDHD2, whose mutations cause spastic paraplegia type 54, enhances lipophagy via engaging ATG8 family proteins.Semantic proximity Read

A conserved ATG2‐GABARAP family interaction is critical for phagophore formationSemantic proximity Read