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Spatial Transcriptomics Using Archived Formalin-Fixed Paraffin-Embedded Core Needle Biopsy Tissues Revealed Unique Transcriptomic Signatures in Kidney Transplant Rejections

2025-04-15

Abstract excerpt

Clinical core needle biopsies present challenges for transcriptomic analysis due to limited tissue volume. In this study, we determined the feasibility of using spatial transcriptomics to evaluate rejection on formalin-fixed paraffin-embedded (FFPE) core needle biopsies from human kidney allografts. We demonstrated that non-rejection, active antibody mediated rejection (AMR), acute cell mediated rejection (TCMR) a...

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Literature Corpus work: 0d456bc1-1af3-5b49-9b75-52456c0e1196
DOI: 10.1101/2025.04.08.647600

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