Article

Structural Basis for C <sup>8</sup> methylation of 23S ribosomal RNA by Cfr

2026-03-02

Abstract excerpt

Cfr methylates C 8 of adenosine 2503 (A2503) in 23 S ribosomal RNA (rRNA) and will also methylate C 2 of A2503 after methylating C 8 . C 8 methylation confers resistance to more than five classes of clinically used antibiotics, highlighting it as a worrisome mechanism of antibiotic resistance. Here, we report the structure of Cfr, determined by cryogenic electron microscopy (Cryo-EM). Despite its small size (...

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Literature Corpus work: c7957a91-84e5-5126-8f8f-3e137faedf69
DOI: 10.64898/2026.02.27.707579

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