Article
Distinction between the Cfr methyltransferase conferring antibiotic resistance and the housekeeping RlmN methyltransferase.
Antimicrobial agents and chemotherapy - 1 Aug 2013
Atkinson Gemma C, Hansen Lykke H, Tenson Tanel, Rasmussen Anette, Kirpekar Finn, Vester Birte
Abstract excerpt
The cfr gene encodes the Cfr methyltransferase that primarily methylates C-8 in A2503 of 23S rRNA in the peptidyl transferase region of bacterial ribosomes. The methylation provides resistance to six classes of antibiotics of clinical and veterinary importance. The rlmN gene encodes the RlmN methyltransferase that methylates C-2 in A2503 in 23S rRNA and A37 in tRNA, but RlmN does not significantly influence...
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