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Article

Site specific target binding controls RNA cleavage efficiency by the Kaposi’s sarcoma-associated herpesvirus endonuclease SOX

2018-05-13

Abstract excerpt

During lytic replication of Kaposi’s sarcoma-associated herpesvirus (KSHV), the gene expression landscape of a cell is remodeled to evade the immune response and create an environment favorable to viral replication. A major driver of these gene expression changes is a virally encoded, messenger RNA (mRNA)-specific endonuclease termed SOX. SOX cleaves the majority of cytoplasmic mRNAs, but does so at specific inter...

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Literature Corpus work
c77978a5-f992-552b-a934-a1835d01f871
DOI
10.1101/320929
Open publication

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Site specific target binding controls RNA cleavage efficiency by the Kaposi’s sarcoma-associated herpesvirus endonuclease SOXDOI 10.1101/320929
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