Article

Nuclear-cytoplasmic compartmentalization of the herpes simplex virus 1 infected cell transcriptome is co-ordinated by the viral endoribonuclease vhs and cofactors to facilitate the translation of late proteins

2018-09-12

Abstract excerpt

HSV1 encodes an endoribonuclease termed v irion h ost s hutoff (vhs) that is produced late in infection and packaged into virions. Paradoxically, vhs is active against not only host but also virus transcripts, and is involved in host shutoff and the temporal expression of the virus transcriptome. Two other virus proteins - VP22 and VP16 – are proposed to regulate vhs to prevent uncontrolled and lethal mRNA degr...

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Literature Corpus work: 0d3e3221-f27b-5fd3-91ba-81de2a02f2b3
DOI: 10.1101/415497

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