Article

The cut site specificity of the influenza A virus endoribonuclease PA-X allows it to discriminate between host and viral mRNAs

2022-07-09

Abstract excerpt

Widespread shutoff of host gene expression through RNA degradation is an advantageous way for many viruses to block antiviral responses. However, viruses still need to maintain expression of their own genes and host genes necessary for replication. The influenza A virus host shutoff endoribonuclease PA-X solves this problem by sparing viral mRNAs and some host RNAs. To understand how PA-X distinguishes between RNA...

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Literature Corpus work: 4abdeedc-2b3b-5116-9922-1c9683c1f04c
DOI: 10.1101/2022.07.08.499385

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