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Article

A high-resolution view of RNA endonuclease cleavage in Bacillus subtilis.

Nucleic acids research - 24 Jan 2025

Taggart James C, Dierksheide Kathryn Julia, LeBlanc Hannah J, Lalanne Jean-Benoît, Durand Sylvain, Braun Frédérique, Condon Ciarán, Li Gene-Wei

Abstract excerpt

RNA endonucleases are the rate-limiting initiator of decay for many bacterial mRNAs. However, the positions of cleavage and their sequence determinants remain elusive even for the well-studied Bacillus subtilis. Here we present two complementary approaches-transcriptome-wide mapping of endoribonucleolytic activity and deep mutational scanning of RNA cleavage sites-that reveal distinct rules governing the...

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Identifiers

PMID: 39883015
DOI: 10.1093/nar/gkaf030
PMCID: PMC11780869

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