Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Host Shutoff Is a Conserved Phenotype of Gammaherpesvirus Infection and Is Orchestrated Exclusively from the Cytoplasm

8 Jul 2009

Abstract excerpt

Lytic infection with the two human gammaherpesviruses, Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV), leads to significant depletion of the cellular transcriptome. This host shutoff phenotype is driven by the conserved herpesviral alkaline exonuclease, termed SOX in KSHV and BGLF5 in EBV, which in gammaherpesviruses has evolved the genetically separable ability to target cellular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to Parvovirus B19 Infection Studies
Share to Viral-associated cancers and disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19587049
DOI: 10.1128/jvi.01051-09

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Host Shutoff Is a Conserved Phenotype of Gammaherpesvirus Infection and Is Orchestrated Exclusively from the CytoplasmPMID 19587049Read ↗

The exonuclease and host shutoff functions of the SOX protein of Kaposi's sarcoma-associated herpesvirus are genetically separable.Semantic proximity Read ↗

IL-6 Evades KSHV-Mediated Hyperadenylation repression via CRM1-Dependent Nuclear ExportSemantic proximity Read ↗

Identification of murine gammaherpesvirus 68 miRNA-mRNA hybrids reveals miRNA target conservation among gammaherpesviruses including host translation and protein modification machinerySemantic proximity Read ↗

Dissecting Herpes Simplex Virus 1-Induced Host Shutoff at the RNA LevelSemantic proximity Read ↗

Infection-Induced Retrotransposon-Derived Noncoding RNAs Enhance Herpesviral Gene Expression via the NF-κB PathwaySemantic proximity Read ↗

A Gammaherpesvirus Noncoding RNA Is Essential for Hematogenous Dissemination and Establishment of Peripheral LatencySemantic proximity Read ↗

Epstein-Barr virus induces host shutoff extensively via BGLF5-independent mechanismsSemantic proximity Read ↗

DNA processing by the Kaposi’s sarcoma-associated herpesvirus alkaline exonuclease SOX contributes to viral gene expression and infectious virion productionSemantic proximity Read ↗

Dissecting HSV-1-induced host shut-off at RNA levelSemantic proximity Read ↗

Site specific target binding controls RNA cleavage efficiency by the Kaposi’s sarcoma-associated herpesvirus endonuclease SOXSemantic proximity Read ↗

PAN RNA: transcriptional exhaust from a viral engineSemantic proximity Read ↗

Post‐transcriptional gene regulation by gamma herpesvirusesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.