Article

Employing RNA editing to engineer personalized tumor-specific neoantigens (editopes)

2023-03-19

Abstract excerpt

Increasing the quantity and immunogenicity of neoantigens in tumors is essential for advancing immunotherapy. However, engineering neoantigens remains challenging due to the need for precise, tumor-specific antigen modification without affecting normal cells. To tackle this challenge, we developed Short Precise-Encodable ADAR Recruiting (SPEAR) ADAR-engagers, an approach that uses short guide RNAs to engage the e...

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Literature Corpus work: c7621b9d-9232-51a8-98f2-f5d249cae7fa
DOI: 10.1101/2023.03.16.532918

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