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Genome Editing in Engineered T Cells for Cancer Immunotherapy

1 Sept 2023

Abstract excerpt

Advanced gene transfer technologies and profound immunological insights have enabled substantial increases in the efficacy of anticancer adoptive cellular therapy (ACT). In recent years, the U.S. Food and Drug Administration and European Medicines Agency have approved six engineered T cell therapeutic products, all chimeric antigen receptor-engineered T cells directed against B cell malignancies. Despite...

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PMID: 37694593
DOI: 10.1089/hum.2023.128

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