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Article

Adoptive T cell therapy targeting an inducible and broadly shared product of aberrant mRNA translation

1 Jan 2025

Abstract excerpt

Prolonged exposure to interferon-gamma (IFNγ) and the associated increased expression of the enzyme indoleamine 2,3-dioxygenase 1 (IDO1) create an intracellular shortage of tryptophan in the cancer cells, which stimulates ribosomal frameshifting and tryptophan to phenylalanine (W>F) codon reassignments during protein synthesis. Here, we investigated whether such neoepitopes can be useful targets of adoptive T...

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PMID: 39755122
DOI: 10.1016/j.immuni.2024.12.004

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