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Article

Synthetic multiepitope neoantigen DNA vaccine for personalized cancer immunotherapy.

Nanomedicine : nanotechnology, biology, and medicine - 1 Oct 2021

Yang Xiaoyue, Fan Jiansheng, Wu Yue, Ma Zhiming, Huang Jin, Zhang Ying, Zhou Zhan, Mo Fan, Liu Xuerong, Yuan Hong, Xu Yingchun, Pan Liqiang, Chen Shuqing

Abstract excerpt

Neoantigen-based personalized vaccination has emerged as a viable method for tumor immunotherapy. Here we set up a DNA-based neoantigen vaccine platform with comprehensive identification of individual somatic mutations using whole-exome sequencing (WES) and RNA-seq, bioinformatic prediction of neo-epitopes, dendritic cell (DC)-based efficacy prevalidation of vaccine candidates, optimization of the DNA vaccine and...

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PMID: 34303839
DOI: 10.1016/j.nano.2021.102443

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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