Chronic Polystyrene Nanoplastics Exposure Reprograms Gene Expression, Alternative Splicing, and Disrupts Host–Microbiome–Metabolic Networks to Promote Atherosclerosis in LDLr⁻/⁻ Mice

Abstract excerpt

Although micro- and nanoplastics have been detected in human atherosclerotic plaques, their mechanistic contribution to disease pathogenesis remains poorly defined. Most experimental studies have used microplastics (particles > 1 μm) in non-atherosclerotic animal models or the ApoE⁻/⁻ mouse, relying on short-term exposure or single-pathway analyses, whereas the chronic cardiovascular effects of nanoplastics (< 100...

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• Adipokines, Inflammation, and Metabolic Diseases
• Diet and metabolism studies
• Ginseng Biological Effects and Applications
• Gut microbiota and health
• Liver Disease Diagnosis and Treatment
• Metabolomics and Mass Spectrometry Studies

Identifiers and source

Literature Corpus work

b1820ba3-3849-5efd-89a9-4da0561a6c83

DOI

10.64898/2026.07.09.736446