Article

LDL delivery of microbial small RNAs drives atherosclerosis through macrophage TLR8

2021-01-07

Abstract excerpt

<title>Abstract</title> <p>Macrophages present a spectrum of phenotypes that mediate both the pathogenesis and resolution of atherosclerotic lesions. Inflammatory macrophage phenotypes are pro-atherogenic, but the natural factors that instigate this polarization are largely unknown. Here, we demonstrate that microbial small RNAs (msRNA) are enriched on LDL and drive pro-inflammatory macrophage polarization and cy...

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Literature Corpus work: 3de440b7-7ff1-58df-a3cb-75be51d1b9e9
DOI: 10.21203/rs.3.rs-134271/v1

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