Article

Predicting antifolate resistance in the unculturable fungal pathogen <i>Pneumocystis jirovecii</i>

2025-05-08

Abstract excerpt

Pneumocystis jirovecii is a fungal pathogen causing Pneumocystis pneumonia in humans, mainly in immunocompromised individuals. Infections by P. jirovecii are treated using the antifolate combination drug trimethoprim-sulfamethoxazole (TMP-SMX), targeting the dihydrofolate reductase (DHFR) and the dihydropteroate synthase (DHPS). In recent years, there has been an increase of treatment failure, with no mutations o...

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Literature Corpus work: c739f94d-d857-598f-8a0a-953cf6356720
DOI: 10.1101/2025.05.07.652661

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